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β-Caryophyllene: The Versatile, High-Purity Sesquiterpene Revolutionizing Fragrances, Flavors, and Functional Wellness

· Ingredients Journal

In the dynamic realms of fine perfumery, flavor creation, personal care, and emerging functional wellness, few natural compounds match the bold versatility and enduring impact of β-caryophyllene (also known as beta-caryophyllene or trans-caryophyllene, CAS 87-44-5). This bicyclic sesquiterpene, abundant in essential oils from clove, black pepper, Ceylon cinnamon, lavender, and many spices, delivers a distinctive aroma profile: spicy, woody, citrusy, camphorous, with warm clove-like nuances that evoke dry, dusty, oily wood and faint peppery tenacity.

Its potent, long-lasting character makes β-caryophyllene a cornerstone ingredient for authentic spice accords—clove, pepper, nutmeg, cinnamon—and adds grounding depth to woody, oriental, fougère, green, and spicy fragrance families. Perfumers prize it for enhancing complexity, fixation, and diffusive power in both luxury fine fragrances and everyday functional scents.

Why β-Caryophyllene Excels in Fragrance and Flavor Applications

With its sweet woody-spice, clove, dry, and tenacious scent, β-caryophyllene imparts remarkable persistence that lingers on skin or in the air, dramatically boosting overall composition depth and naturalness.

  • In fine perfumery and aroma compounds: Ideal for recreating realistic clove, pepper, nutmeg, and citrus-spice profiles; provides woody backbone in oriental, fougère, and woody blends; acts as a natural fixative with excellent tenacity.
  • In food and beverage flavoring: Contributes authentic spicy, peppery, and clove notes to savory, baked goods, beverages, and edible systems—FEMA-approved and widely used for its bold flavor impact.
  • In cosmetics, personal care, and household products: Enhances detergents, soaps, lotions, and diffusers with warm, grounding spiciness; supports functional fragrances that deliver long-lasting performance.

Its molecular formula C₁₅H₂₄ and exceptional ≥98% purity (with ≥99% available for premium needs) ensure minimal impurities, maximum potency, and cleaner profiles—surpassing typical industry grades.

Beyond olfactive and gustatory excellence, β-caryophyllene stands out for its well-documented pharmacological properties. As a selective CB2 receptor agonist, it exhibits notable anti-inflammatory, analgesic, anxiolytic, antidepressant, antioxidant, anti-ulcer, and even mosquito-repellent effects. Emerging research continues to highlight its potential in pharmaceutical and nutraceutical formulations, including support for chronic pain relief, skin barrier restoration, neuroprotection, and anti-inflammatory wellness applications—positioning it as a bridge between fragrance innovation and functional health.

Breaking Free from Traditional Limitations: Biosynthetic Innovation

Sourcing high-quality β-caryophyllene traditionally depends on plant extraction, where low natural concentrations lead to high purification costs, limited scalability, and seasonal inconsistencies. Chemical synthesis alternatives often carry environmental drawbacks, including pollution and hazardous byproducts.

Genvera Labs addresses these challenges head-on with cutting-edge microbial biosynthesis technology. This advanced, green platform offers:

  • Precise, scalable production for consistent year-round availability
  • High-purity output (≥98%, up to ≥99%)
  • Zero hazardous emissions and full sustainability—eliminating the ecological footprint of conventional methods
  • Cost-effective efficiency to support growing demand from premium fragrance houses, flavor companies, cosmetics brands, household product manufacturers, and pharmaceutical developers

This bio-based approach aligns seamlessly with global trends toward sustainable, clean-label, and eco-friendly ingredients in luxury and mass-market sectors.

β-Caryophyllene Specifications Overview

  • Product Name: β-Caryophyllene (Caryophyllene, trans-Caryophyllene)
  • CAS Number: 87-44-5
  • Molecular Formula: C₁₅H₂₄
  • Purity: ≥98% (high-purity commercial grade; ≥99% for pharmaceutical/research use)
  • Key Applications: Flavors & Fragrances, Fine Perfumery & Aroma Compounds, Food & Beverage Flavoring, Pharmaceutical & Nutraceutical Formulations, Functional Cosmetics & Personal Care

Genvera Labs' Competitive Advantages

  • Unmatched Purity — ≥99% options deliver superior bioactivity, potency, and impurity-free performance for demanding applications.
  • Sustainable Bio-based Manufacturing — Microbial fermentation replaces resource-intensive extraction and polluting synthesis, supporting green chemistry goals.
  • Tailored Supply Solutions — Customizable specifications, flexible volumes, and expert formulation guidance to fit your precise needs—whether crafting a signature spicy perfume, enhancing a functional wellness product, or scaling flavor systems.

As demand surges for natural, multifunctional ingredients that combine captivating scent/flavor with scientifically backed benefits, β-caryophyllene emerges as an indispensable ally for innovation. Its spicy-woody signature, exceptional longevity, and broad therapeutic potential make it ideal for modern creators seeking authenticity, performance, and sustainability.

Ready to incorporate premium, biosynthesized β-caryophyllene into your next fragrance, flavor, or functional formulation? Contact Genvera Labs for high-purity samples, technical data, or customized support today.

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